碩士 / 靜宜大學 / 應用化學研究所 / 94 / Alginate nanoparticles have gained extensive interest as drug carriers because of the biocompatibility and biodegradability of polymer .Microemulsions are thermodynamically stable system and can be formed spontaneously when properly formulated.
Arbutin is a glycosylated hydroquinone. Its properties are skin whitening by inhibiting melanin synthesis, sunscreen agent and antioxidant, but it’s a hydrophilic drugs . Researching for enhancement methods of drug percutaneous absorption is one of the important topics on medications. A major problem in transdermal drug delivery is the low penetration rate of substances through the barrier of skin, the stratum corneum, which consists of corneocytes embedded in a lipid matrix. One of the methods to increase the rate across the skin is encapsulation of drugs in alginate nanoparticles.
In our study, the drug was encapsulated in nanoparticles were applied on the results by various preparation formulations, in vitro drug release studies and transdermal drug delivery system.
The results demonstrated that the diameter of prepared nanoparticles was controlled in a range of 10~200nm. Factors included molecular weight, concentration of sodium alginate, and initial concentration of the cross-link agent, have been examined to investigate effect on particle size and zeta potential. The results of alginate NP on arbutin delivery, penetration across skin was 82% of initial doses. Free drug and arbutin nanoemulsion resulted in transport was 35% and 57% of initial doses. Based on the results, the amount of absorbed arbutin have additive effect with a nano-encapsulation technology
Accordingly, alginate nanoparticle could facilitate the transport of hydrophilic molecules through skin. But the mechanism of the transdermal drug delivery system is needed further research and development.
| Identifer | oai:union.ndltd.org:TW/094PU005500010 |
| Date | January 2006 |
| Creators | Chia-hang Chiang, 姜佳函 |
| Contributors | Kwan Chang-Chin, 官常慶 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 138 |
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