碩士 / 臺北醫學大學 / 保健營養學系 / 94 / Due to the improvement of life standard, increase of alcohol consumption and obesity. The incidence and prevalence rates of gout among Taiwanese population keep a tendency of growing. The drug for hyperuricemia, Allopurinol, causes serious sensitive reaction to susch patients. Therefore, it would be optimal to moderate the level of higher blood uric acid by the way of adjusting the composition of diet. The effect of oral administration of Chlorella extract with diet on the level of blood uric acid was examined in human trial. The level of blood uric acid of participants was enhanced by high purine food and the participants were randomly distributed into five groups, regular diet without Chlorella extract, high purine diet with high dose, middle dose, low dose Chlorella extract and regular diet middle dose Chlorella extract. After administration of Chlorella extract, the level of uric acid in the participants was detected and compared among groups. The results showed there was significant decrease in participants’ uric acid at fourth hour after the administration of Chlorella extract. The level of blood uric acid in both middle dose and high dose group significantly decreased, comparing with that of the group of regular diet without Chlorella extract. The level of blood uric acid in high dose group significantly decreased, comparing with that of the group of low dose. The level of blood uric acid in regular diet with Chlorella extract group significantly decreased, comparing with that of the group of regular diet without Chlorella extract. In summary, a dietary supplement of Chlorella extract may be useful to lower down the level of blood uric acid under the condition of high purine diet. Meanwhile, Chlorella extract is a kind of traditional food with no adverse effect at all.
Key words: Chlorella extract, gout, hyperuricemia
| Identifer | oai:union.ndltd.org:TW/094TMC00217021 |
| Date | January 2006 |
| Creators | In-Jye Tsai, 蔡英杰 |
| Contributors | Shih-Yi Huang, PhD, 黃士懿 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 83 |
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