碩士 / 嘉南藥理科技大學 / 藥物科技研究所 / 95 / Alginate is a natural polysaccharide found in brown algae. Alginate is widely used in the pharmaceutical and food, and has been employed as a matrix for the entrapment of drug. Nicotine has some unpleasant side effects, including bad taste and short half-life for some individuals. It can be used in smoking-cessation therapy and acted as a model drug in the study. The purpose of this study was to develop calcium alginate microcapsules with improved properties for controlled delivery and to enhance storage stability of the nicotine. The nicotine microcapsules were manufactured into different sizes of microcapsules by a novel method with combining the mechanical and the chemical method. The effect of sodium alginate, gelatin, PEG 6000 and glycerin added to varying amounts by different ratio, on the morphology, size and encapsulation efficiency of the microcapsules was investigated. The concentration of nicotine was determined by RP-HPLC. The release of nicotine microcapsules was in pH 1.2 HCl-KCl buffer and in pH 7.4 phosphate buffer solution.The physicochemical properties of nicotine microcapsules were determined by differential scanning calorimetry (DSC), Fourier-Transform Infrared Spectrometer (FTIR). The emulsification technique yielded particle sizes ranging from 2134.2μm～1854.0μm (formulation B) and 764.4μm～553.3μm (formulation S) of nicotine-sodium alginate microcapsules. The mean encapsulation efficiency of nicotine microcapsules ranged from 101.8％～92.0％（formulation B）and 77.7％～53.4％（formulation S） respectively. Nicotine microcapsules resulted in wrinkled and cavernous on the surface and formed a reticulated structure on the inside. The DSC and FTIR measurements indicated that the chemical interaction did not occur among the components during manufacturing processes and lyophilized microcapsules. The release profiles were fitted very well by the Higuchi release model. Using a novel and easy method for the nicotine microcapsules manufacture of controlled size and changed the matrix performance allowed the controlled release of nicotine.
| Identifer | oai:union.ndltd.org:TW/095CNUP5549004 |
| Date | January 2007 |
| Creators | Pei-Shan Wu, 吳佩珊 |
| Contributors | Heng-Hong Lin, 林恆弘 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 130 |
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