碩士 / 高雄醫學大學 / 天然藥物研究所碩士班 / 95 / Thirty-one compounds were isolated from the MeOH extracts of Anisomeles Indica. These include seven diterpenoids: ovatodiolide (1), 4,5-epoxovatodiolide (2), 4??-hydroxy-5-enovatodiolide (3), 4??-hydroxy-5-enovatodiolide (4), 4-methylene-5??-
hydroxyovatodiolide (5), 4-methylene-5??-hydroxyovatodiolide (6) and 4-methylene-5-oxovatodiolide (7); seven flavonoids: apigenin (8), terniflorin (9), apigenin 7-O-??-D-(6′′-cis-p-coumaroyl) glucoside (10), 5, 8, 4′-trihydroxy-7, 3′-dimethoxyflavone (11), anisofolin A (12), anisofolin B (13) and prunin-6′′-p-coumarate (14); four triterpenoids: masmalic acid (15), 3-O-trans-p-coumaroylmaslinic acid (16), hederagenin (17) and arjumolic acid (18); three indoles: indole-3-carboxylic acid (19), indole-3-carboxylic acid methyl ester (20) and indole-3-carbaldehyde (21); five benzenoids: p-hydroxybenzoic methyl ester (22), p-hydroxybenzoic acid (23), p-hydroxycinnamic methyl ester (24), 3,4-dihydroxycinnamic methyl ester (25) and anisovatodside (26); five steroids: 6′-(β-sitostery-3-O-β-D-glucopyranosidyl)-hexadecanoate (27), the mixture of β-Sitosteryl (28) and β-sitigmasteryl glucoside (29) and the mixture of β-Sitosterol (30) and β-sitigmasterol (31). Among them, 3~5, 7 and 10 are new compounds; 11, 15~22, 25 and 27 are isolated for the first time from this plant.
In biological tests, the diterpenoids 1~7 showed cytotoxicity against several cancer cell lines and inhibitory effect on platelet aggregation. Furthermore, 1, 8, and 11~14 showed anti-inflammation activity.
| Identifer | oai:union.ndltd.org:TW/095KMC05068007 |
| Date | January 2007 |
| Creators | Yu-Li Chen, 陳俞利 |
| Contributors | Yang-Chang Wu, 吳永昌 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 210 |
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