碩士 / 國立暨南國際大學 / 生物醫學科技研究所 / 95 / The major function of melanogenesis is to prevent cells damage from the attack
of UV light. Over-production of melanin may result in hyperpigmentation and
melanoma. Tyrosinase is the key enzyme in melanogenesis. It catalyzes the
rate-limiting redox reaction of melanogenesis. Consequently, the inhibition of
tyrosinase activity or suppression of its expression may lead to reduce melanogenesis.
c-Phycocyanin (CPC) is a water-soluble protein with characteristics of anti-oxidant
and scavenging of free radicals. In the previous studies, the inhibitory mechanism of
CPC on B16F10 melanogenesis was studied. The results indicated that CPC activated
the activity of ERK and suppressed the activity of CREB, which led to diminished
level of MITF. Moreover, suppression of PKC-beta I by CPC might cause lowered
activity of tyrosinase, which further caused reduced level of melanogenesis. In
addition, CPC engulfed into B16F10 through endocytosis and then transferred into
nucleus was determined by confocal microscopic analysis.
| Identifer | oai:union.ndltd.org:TW/095NCNU0114004 |
| Date | January 2007 |
| Creators | Szu-Yen Yang, 楊思燕 |
| Contributors | Li-Chen Wu, 吳立真 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 65 |
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