碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 95 / Five new diterpenes, GN67-12-5-4-2 (1)、GN67-12-6-4-2 (2)、GN67-20-4-3 (3)、GN67-25-6-1 (4)、GN67-12-5-12-1 (5) and four known terpenoides, GN67-12-5-12 (6)、GN67-28-5-3-3 (7)、GN67-28-5-4 (8)、GN67-23-4 (9) were isolated from the methylene chloride solubles of the Formosan soft coral Cespitularia hypotentaculata.
Three new cytotoxic sesquiterpenes, GN78-14-3a-B (10)、GN78-22-8I-B (11)、GN78-17-3a-B (12) and five known terpenoides, GN78-12-5-B-G (13)、GN78-14-3a-N (14)、GN78-22-8-W (15)、GN78-22-8-H (16)、GN78-24-5-Q (17) were isolated from the Formosan soft coral Paralemnalia thyrsodes
Three known compounds, GN72-9-8-J (18)、GN72-7-4-2 (19)、GN72-19-6-8-E (20) were isolated from the methylene chloride solubles of the Formosan soft coral Dendronephthya divaricata
The structure of 4 was further confirmed by X-ray crystallographic analysis and the configuration of the hydroxyl at C-6 of 5 was further determined by Mosher’s reactions. It was suggested that the C-6 has the S configuration.
The inhibition of these metabolites toward the pro-inflammatory proteins (iNOS and COX-2) expression was also investigated. Compound 17 showed more specific inhibition against the up-regulation of the pro-inflammatory iNOS protein of LPS-stimulated RAW264.7 macrophage cells.
| Identifer | oai:union.ndltd.org:TW/095NSYS5270033 |
| Date | January 2007 |
| Creators | En-hung Lin, 林恩弘 |
| Contributors | Chang-Yih Duh, 杜昌益 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 360 |
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