碩士 / 國立臺灣海洋大學 / 食品科學系 / 95 / Abstract
Recently, oxidative stress has been implicated in the progression of Alzheimer’s disease and antioxidants may protect neural cells from this attack. Astaxanthin (AST) is a carotenoid found in marine animals and alga. Several previous studies have demonstrated that AST exhibits a wide variety of biological activities including antioxidant, antitumor effects. In this study prove 50 □M AST reduce DNA fragmentation caused by H2O2 through inhibition of about 50% of caspase activity and 41.5% of mitochondria transmembrane potential. Morover inhibition from 26.17% to 67.7% of beta-amyloid(A□) fibrils formation is with time dependent manner. Further 100 □M AST can inhibit neuroinflammation factor include NO release, Ca2+ influx and 50% of ERK phosphorylation.
In conclusion, AST may against H2O2-/A□- induced neurotoxicity through inhibiting apoptosis signalling pathway and reducing expression of neuroinflammation factor and protein. Furthmore, AST has potential on apply to prevent neurodegenerative disorders (EX: Alzheimer’s disease).
Keywords: Astaxanthin, Neuroprotection, Hydrogen peroxide, Amyloid-□, apoptosis, Neuroinflamation
| Identifer | oai:union.ndltd.org:TW/095NTOU5253014 |
| Date | January 2007 |
| Creators | Yu-Ting Huang, 黃鈺婷 |
| Contributors | Zwe-Ling Kong, 龔瑞林 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 74 |
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