碩士 / 臺北醫學大學 / 藥學研究所 / 95 / Liver injury is the most common side effect during the first-line antituberculosis therapy. There are many risk factors of liver injury, such as age, gender, nutrition, alchol, viral hepatitis and gene. It has been proved that the genetic variations of metabolic enzyme increased the incidence rate of liver injury. However, recent studies showed that Human Organic Anion Transporting Polypeptide 1B1(OATP1B1) which transports substrates in human bodies is related to the distribution of rifampin. It is very important to study if the genetic variations of OATP1B1 affect the distribution of rifampin, and lead to liver injury. The transporting ability of OATP1B1 is genetically variant, and consequently influences the amount of drug transported to liver. The distribution of OATP1B1 genotypes are depended on the ethnics. There are no related studies avalible on the correlation between OATP1B1 genotypes and hepatotoxicity during antituberculosis therapy for Taiwanese population.
The primary aim of this study was to discuss the distribution of OATP1B1 genotypes in patients with and without liver injury. The secondary aim was to compare the liver function between the OATP1B1 wild-type and mutant-type. This study included 97 patients whom diagnosed tuberculosis in Taipei Municipal Wan Fang Hospital. The patients’ medical charts were reviewed and their peripheral blood samples were collected. These samples were analysed by PCR-RFLP (polymerase chain reactions- restriction fragment lenth polymorphism) to classify into the genotypes OATP1B1*1b, OATP1B1*5 and OATP1B1*15. This study showed that the allele frequency of the study population, OATP1B1*1b is the highest (64.9%), wild type-OATP1B1*1a is intermediate (24.2%), and OATP1B1*5 is the lowest (0.5%). OATP1B1*5 usually coexisted with OATP1B1*1b, which was classified as OATP1B1*15. However, the distribution of different OATP1B1 genotypes between the groups with and without liver injury are not statistically significant. OATP1B1*1b, OATP1B1*5 and OATP1B1*15 were not statistically significant risk factors of liver injury during antituberculosis therapy . Further studies are warranted to investigate the correlation between the genotypes of OATP1B1 and liver injury during antituberculosis therapy.
| Identifer | oai:union.ndltd.org:TW/095TMC05551007 |
| Date | January 2007 |
| Creators | Hsiang-Mei Chen, 陳香郿 |
| Contributors | 陳香吟 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 105 |
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