碩士 / 國立陽明大學 / 放射醫學科學研究所 / 95 / Abstract
The hippocampus is an important structure for memory formation and spatial orientation that is particularly vulnerable to acute or chronic injury. Interruption of the cardiac output results in a global cerebral ischemia which is characterized morphologically by a selective neuronal damage in the hippocampus.
Diffusion Tensor Imaging(DTI) provides a non-intrusive way for detecting water diffusion in tissue which is affected by the presence of barriers, including cell membranes and myelin fibers. Water diffusion can be specified by using indices of diffusion such as Mean Diffusivity(MD) and Fractional Anisotropy(FA).
This study investigated diffusion tensor imaging and tissue histopathology(H&E stain) on subregion(CA1 and DG) of both adult and aged gerbil hippocampus following global ischemia. On the CAl of hippocampus, we found that not only the first eigenvector map presented disorderliness but also the indices of diffusion showed significant alteration. Furthermore, the variation of fractional anisotropy appeared different pattern between adult and aged group.
| Identifer | oai:union.ndltd.org:TW/095YM005605009 |
| Date | January 2007 |
| Creators | Hsuan-cheng Lin, 林炫成 |
| Contributors | Ching-Po Lin, Tsong-Hai Lee, 林慶波, 李宗海 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 52 |
Page generated in 0.0127 seconds