碩士 / 嘉南藥理科技大學 / 營養與保健科技研究所 / 96 / The aim of this study was to evaluate the influence of supernatant from ethanolic extracts of Morinda citrifolia L. leaf ( LES ) on the oxidative status of mice fed with high fat diet. Seventy mice were divided into seven groups. The AIN 76A regular diet (A) or high-fat diet (F), and F group with either 0.025% quercetin (Q), 0.005% and 0.025% rutin (RL, RH), 0.2% and 1%LES (LEL, LEH) for a 80-day period. Results indicated that quercetin, rutin and LES do not affect final body weight, daily food intake, feed efficiency and relative liver weight of mice when compared to F group. However, LEH group could significantly increase trolox equivalent antioxidant capacity (TEAC), decrease lipid peroxidation and mild increase glucose-6-phosphate dehydrogenase (G6PD) in blood cells in mice. Moreover, LEH group have higher red blood count, hemoglobin and hematocrit that implied significantly the protection effects on RBC against oxidative stress induced by high fat diet. LEH group also could increase superoxide dismutase (SOD) and G6PD activity in liver of mice. Taken the data of RL or RH groups together, rutin have the same tendency towards antioxidative capacity in blood cells and liver of mice when compared to LES, except for significance level. In conclusion, LES have protection effects on blood cells and liver tissue in mice from oxidative stress induced by high fat diet. The effectiveness of LES relates to the dose of usage, and protection effects against oxidative stress of LES may not only attribute to rutin but also to other bioactive components.
| Identifer | oai:union.ndltd.org:TW/096CNUP5255004 |
| Date | January 2008 |
| Creators | Yun-I Chang, 張允一 |
| Contributors | Shih-Ying Chen, Tsuey-Pin Lin, 1.陳師瑩, 2.林翠品 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 115 |
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