碩士 / 中臺科技大學 / 放射科學研究所 / 96 / This study intended to use chitosan as base for making thermosensitive and in situ formed hydrogel for the delivery of therapeutic radio and chemo pharmaceuticals. The thermosensitive aqueous solution from chitosan and β-glycerophosphate (C/GP) mixture is flowable liquid at room temperature, whereas, it is transformed to semi-solid gel near body temperature. Thus, we combined C/GP solution with therapeutic 188Re-Tin colloid radiopharmaceutical and chemotherapy drug doxorubucin in an attempt to develop a novel treatment mode in nuclear medicine. The preparation procedure of chitosan-based in situ formed hydrogel system and 188Re-Tin colloid pharmaceuticals was well established, also the relative characterization was known herein. Through the in vitro kinetic study, the C/GP hydrogel not only retarded the release of chemodrug but also immobilized the Radio-labeled drug locally. As well, the scintigraphic image also indicated localization of C/GP/188Re-Tin colloid in the muscle site up to 48 h postinjection. In cell culture study, the Dox drug show well inhibition ability in MCF-7 growth and have good time-dependent response herein. Our study demonstrated that it is feasible to use chitosan-based hydrogel for local delivery of chemotherapeutics and radiation. Results from this study suggest further in vivo study
| Identifer | oai:union.ndltd.org:TW/096CTC05605001 |
| Date | January 2008 |
| Creators | Feng-Yun Huang, 黃蜂運 |
| Contributors | Bor-Tsung Hsieh, 謝栢滄 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 113 |
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