碩士 / 國立交通大學 / 環境工程系所 / 96 / A closed-system algal toxicity test was applied to evaluate the toxicity of secondary and tertiary propargylic alcohols to Pseudokirchneriella subcapitata. The effects of propargylic alcohols were evaluated by three kinds of response endpoints, i.e., dissolved oxygen production, cell density, algal growth rate. Median effective concentraton (EC50) were estimated using the Probit model. The quantitative structure-activity relationships (QSARs) were established based on the 1-octanol/water partition coefficient (logP) and an electronic parameters-lowest unoccupied molecular orbit (Elumo).
The result shows that the highest sensitivity is cell density between three end points, and the toxicity of secondary and tertiary propargylic alcohols is correlation to the position of alkynyl and hydrophobicity, respectively. Compare with sensitivity for other species, BOD-FY > BOD-DO > Fathead minnow > BOD-GR > Tetrahymena Pyriformis。
The QSAR about the secondary propargylic alcohols has a good fit (R2 = 0.852~0.926) with the logP and Elumo except three outliers that alkynyl attached to 1-position. The QSAR using logP for tertiary propargylic alcohols has a good fit (R2 = 0.914~0.965). Moreover, a cut-off value approach is proposed to determine whether NOEC or EC10 should be chosen for estimating low toxic effects. The results indicate that NOEC offers better protection to test organisms than EC10.
| Identifer | oai:union.ndltd.org:TW/096NCTU5515023 |
| Date | January 2008 |
| Creators | Je-Wei Fan, 范哲偉 |
| Contributors | Chung-Yuan Chen, 陳重元 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 104 |
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