碩士 / 國立東華大學 / 海洋生物科技研究所 / 96 / In continuation of our research on the chemical constituents of Formosan sea whip gorgonian coral, twelve briarane-related natural products, including eight new 8-hydroxybriarane diterpenoids, junceols A–H (1–8), along with four known briaranes, junceellin (9), juncenolide A (10), juncenolide F (11) and umbraculolide A (12) were isolated from the organic extract of Junceella juncea. In above compounds, junceol C (3) is the briarane which possesses the highest molecular weight in briarane derivatives. Junceols F (6) and G (7) are the first briaranes possessing 2-methylbutanoxy groups in structures. The structures, including the relative configurations of compounds 1–12 were established by spectroscopic methods and by comparing the related spectral and physical data with those of previous reported briarane analogues.
In the biological assay, compounds 2, 3 and 11 were found to show inhibitory effects on superoxide anion generation by human neutrophils. Compound 4 exhibited significant cytotoxicity, and 6–8 revealed moderate cytotoxicity against human T-cell acute lymphoma (CCRF-CEM). Moreover, compounds 4 and 8 displayed moderate cytotoxicity against human colon carcinoma (DLD-1) cells.
| Identifer | oai:union.ndltd.org:TW/096NDHU5270007 |
| Creators | Chen-Hao Pai, 白鎮豪 |
| Contributors | Ping-Jyun Sung, 宋秉鈞 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 225 |
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