碩士 / 弘光科技大學 / 生物科技研究所 / 97 / Abstract
The carotenoid pigment astaxanthin has important applications in the nutraceutical, cosmetics, food and feed industries. Astaxanthin is a strong coloring agent and a potent antioxidant .In this study we examined whether astaxanthin had a neuroprotection against H2O2-induced injury in PC12 cells. Calcium and lipid peroxidation play important roles in oxidative stress-induced cellular injury and apoptosis,which ultimately cause cell death. Pretreatment of PC12 cells with astaxanthin improved the cell viability, decreased malondialdehyde level and attenuated the intracellular Ca2+ concentration, and the reduced NO production in the H2O2-induced injury in PC12 cells.Furthermore, the [Caspase-3/pro-Caspase-3] and [Bax/Bcl-2] ratios were slightly low in H2O2-induced injury in PC12 cells after astaxanthin treatment . In summary, this study demonstrates that astaxanthin is able to relieve H2O2-induced oxidative stress and apoptosis in PC12 cells, at least in part, by Ca2+ antagonism and antioxidant mechanisms.
| Identifer | oai:union.ndltd.org:TW/097HKU05111005 |
| Date | January 2009 |
| Creators | Jueen-Ya Chiou, 邱俊雅 |
| Contributors | Chi-Huang Chang, Chamg-Cherng Chyau, 張基煌, 喬長誠 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 46 |
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