碩士 / 國立彰化師範大學 / 統計資訊研究所 / 97 / In the late 1950s in the southwestern coast of Taiwan, the residents had used high-arsenic artesian well water for a long time. In these areas, it is believed that the long-term arsenic exposure was associated with the high standardized mortality ratios (SMRs) of lung cancer and bladder cancer as well as the endemic of black foot disease (BFD). In response, a tap-water supply system was installed in the early 1960s in these areas. In the next 20 years, the SMRs declined gradually, though the incidence rates were still among the top 10% in Taiwan’s villages and towns.
This study aims to investigate the lung cancer and bladder cancer incidence trends after the improvement of water supply system in the southwestern coast of Taiwan. We analyzed the epidemiological data on lung cancer and bladder cancer (International Classification of Disease, 9th revision code 162 and 188) obtained from the Taiwan Cancer Registry, for the period from 1979 to 2003 in Taiwan and in the BFD-endemic areas. The incidence trends of both cancers in both areas were evaluated by using the Age-Period-Cohort analysis.
The results show that the incidence rates increased with the later period and birth-cohort, except that the incidence rates of both cancers were higher in the BFD-endemic areas than in Taiwan. The differences in the incidence rates of lung cancer between the BFD-endemic areas and Taiwan steadily decreased in the later cohort group (1934~1938), and the incidence rate of lung cancer was 1~2 times higher in the BFD-endemic areas than in Taiwan in the final cohort group (1949~1953). Whether the two areas will have equal incidence rates of lung cancer is to be assessed by future research.
The differences in the incidence rates of bladder cancer between the BFD-endemic areas and Taiwan significantly decreased (p-value<0.05) in the last two cohort group (1944~1948 and 1949~1953), and the incidence rate of bladder cancer of the residents who had used high-arsenic artesian well water for more than 30 years were 20 times higher than that in Taiwan. It is found that for the residents who didn’t drink high-arsenic artesian well water after 25 years old, the incidence rate of bladder cancer decreased by 4~8 times. However, it still needs to be investigated why there exists the relatively higher incidence rate of bladder cancer in the BFD-endemic areas even after the improvement of the water supply system.
| Identifer | oai:union.ndltd.org:TW/097NCUE5506003 |
| Date | January 2009 |
| Creators | Chia-Ling Lu, 呂佳玲 |
| Contributors | Ie-Bin Lin, 連怡斌 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 76 |
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