碩士 / 國立臺灣海洋大學 / 生物科技研究所 / 97 / During embryogenesis,the processes of cell differentiation, organogenesis and response to environmental stimulation are all controlled by various gene regulation system. The bHLH-PAS protein family play important roles in vertebrate development 、xenobiotic metabolism and hormone signal transduction. In the bHLH-PAS mediated pathway, ARNT can dimerize with AHR 、HIF and SIM to regulate variety gene. It was shown that repression of arnt2 gene caused severe defect in neuron development.
Previously,it was shown that blacking arnt2 translation resulted in sever defect of glial cell development. In here, we use two different arnt2 morpholino (MO2) to verify the function of arnt2 on glial cell development if appear that. the two new arnt2 morpholino blacked gilal cell development including olgodendrocyte、astrocyte、shwann cell and radil glial cell differention like previous arnt2 morpholino did. we have also confirned that arnt2 knockdown inhibited mbp expression and suppress myelin sheath formation.
| Identifer | oai:union.ndltd.org:TW/097NTOU5111033 |
| Date | January 2009 |
| Creators | Chun-Ta Ma, 馬駿達 |
| Contributors | Chin-Hwa Hu, Tsou-Shiung Wen, 胡清華, 鄒文雄 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 58 |
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