碩士 / 大仁科技大學 / 製藥科技研究所 / 97 / According some papers showed that 52% of respondents with some degree of erectile dysfunction and 35% of 40–70 years old men with moderate or complete impotence recently. Erectile dysfunction, known clinically as disorder about erection, is a medical problem affecting young and old men.
There are many traditional Chinese medicines in the market have the increase physical energy effect, include Eucommia ulmoides Oliv., Epimedium brevicornum Maxim., Arctium lappa L. fruits etc. The Epimedium brevicornum Maxim was investigated by some scholars in some studies. Epimedium brevicornum Maxim. crude extract and fraction extract possessed the 39% and 34% individually relaxation effect on rabbit corpus cavernosum smooth muscle (CCSM) at 1mg/ml. This effect indicated that Epimedium brevicornum Maxim was helpful to erection effect.
At present, PDE5 inhibitors were used for the treatment of erectile dysfunction but many side-effects in cardiovascular disorders and fatal cases have ever occurred. The aim of this study is to find folk medicine to improve erectile dysfunction and more safe than PDE5 inhibitor. First, Fructus Arctii or fruits Arctium lappa L. (FAL) were prepared by different solvents and metho, we could obtain crude extracted included: FAL extract-A、B、C & D. We found that FAL extracts-C and D (at 100μg/ml) were 90.58 % ( p<0.001) and 100% ( p<0.001) relaxation individually on CCSM. Then FAL extract-D was used to fraction partition by different solvents and five fractional extracts were obtained, included HxF、DcF、EaF、BtF & WtF. Three fractional extracts: DcF、EaF and BtF(at 100μg/ml) were 100%( p< 0.001)、100%( p< 0.001) and 96.88%( p< 0.001) on CCSM for the maximal relaxation effect. Additionally, the relaxation effect of FAL was mediated byα1 adrenergic receptor to inhibit the CCSM contraction.
In conclusion, the contraction of CCSM was actually inhibited by FAL and the relaxation effect was through inhibition of the α1 adrenergic receptor. So we suggested that FAL might be helpful to improve erectile dysfunction.
| Identifer | oai:union.ndltd.org:TW/097TAJ05549008 |
| Date | January 2009 |
| Creators | Hsin-Wei Chen, 陳信維 |
| Contributors | Daih-Huang Kuo, 郭代磺 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 133 |
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