碩士 / 中臺科技大學 / 放射科學研究所 / 98 / This study used chitosan as base for making thermosensitive and in situ formed hydrogel assessing the efficacy of treatment of liver cancer. Chitosan /β-glycerophosphate (C / GP) hydrogel is a biocompatible and biodegradable of a non-toxic and natural advantages, it can combined with rhenium -188 which include higher energy beta emission and doxorubicin （C/GP/188Re-Tin colloid/Dox）for the treatment of liver cancer. This study has been completed C/GP/188Re-Tin colloid / Dox in vitro release, confirmed by the experimental C / GP hydrogel system can be effectively combined 188Re-Tin colloid and Dox to achieve slow release of remaining live up to 48 hours. However, in C/GP/188Re-Tin colloid of animal bio-distribution and preliminary efficacy assessment by the nuclear medicine studies, also showed C/GP/188Re-Tin colloid directly to 48 hours after injection of tumor is still no significant proliferation. In the efficacy evaluation, tumor size, measured by liver biopsy and liver pathology results confirmed C/GP/188Re-Tin colloid could inhibit tumor cell growth and to improve treatment.
| Identifer | oai:union.ndltd.org:TW/098CTC05605013 |
| Date | January 2010 |
| Creators | Wen-min Chen, 陳文敏 |
| Contributors | Bor-tsung Hsieh, 謝栢滄 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 71 |
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