碩士 / 國立東華大學 / 海洋生物科技研究所 / 98 / In the continuing search for novel substance from marine invertebrates originally distributed in Taiwan waters. The octocoral Briareum excavatum was transplanted to the
culturing tanks located in National Museum of Marine Biology & Aquarium (NMMBA) for its interesting chemical constituents. This study had led to the isolation of nine briarane derivatives, including seven new compounds excavatoids E−K (1−7), and two known metabolites, excavatolide X (8) and briaexcavatolide L (9). In
addition, a known carotenoid metabolite loliolide (10) was also found in B. excavatum. The structures of compounds 1−10 were determined by spectroscopic methods. The structures of excavatoid E (3) and loliolide (10) were further confirmed by X-ray data analysis.
In biological activity assays, the cytotoxicity of compounds 1−10 toward DLD-1, CCRF-CEM, HL-60, and IMR-32 tumor cells were studied. These data showed that
excavatoid H (2) exhibited margin cytotoxicity against DLD-1 and CCRF-CEM cells. In addition, some of these compounds such as 1, 2, 3, 5, 9, and 10 have displayed mild inhibitory effects on superoxide anion generation by human neutrophils. Compounds 3, 5, and 10 showed mild inhibitory effects on human neutrophil elastase release.
| Identifer | oai:union.ndltd.org:TW/098NDHU5270001 |
| Date | January 2010 |
| Creators | Bo-Yuan Chen, 陳柏元 |
| Contributors | Ping-Jyun Sung, 宋秉鈞 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 230 |
Page generated in 0.0124 seconds