碩士 / 國立東華大學 / 海洋生物科技研究所 / 98 / The studies on the chemical constituents of gorgonian coral Ellisella robusta collected
off the coast of southern Taiwan, it have resulted in the isolation of nine briarane-type
diterpenoids, including two new compounds, 12-epi-fragilide G (1) and robustolide L (2),
along with seven known metabolites, robustolides B (3), D (4), G‒I (5‒7),
(–)-2-deacetyljuncellin (8), and (–)-3-deacetyljuncellin (9). In addition, the soft coral
Briareum violacea yielded a new cembranoid diterpenoid 10, and two known cembranoids,
pachyclavulariolide (11) and pachyclavulariolide I (12). The structures of compounds 1−12
were determined by spectroscopic methods. The structure, including the absolute
configuration of 6 and 10 were further confirmed by a single-crystal X-ray diffraction
analysis.
In the biological activity examination, compounds 2 and 4 were found to show weak
cytotoxicity toward the IMR-32 and DLD-1 tumor cells. Compounds 1, 3−12 showed weak
inhibitory effects on elastase release by human neutrophils, and compounds 3 and 4 has
displayed mild inhibitory effects on superoxide anion generation by human neutrophils.
| Identifer | oai:union.ndltd.org:TW/098NDHU5270008 |
| Date | January 1900 |
| Creators | Yu-Chia Chang, 張祐嘉 |
| Contributors | Ping-Jyun Sung, 宋秉鈞 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 220 |
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