碩士 / 臺北醫學大學 / 藥學研究所 / 98 / The purpose of the study is the development of microencapsulated formulation for improving the stability of the Astaxanthin. Astaxanthin is an antioxidant which could be artificially synthesized or extracted from natural resources and is broadly applied to aquaculture and pasturage industry. To date, numerous research indicated Astaxanthin can improve cardiovascular disease, oxidation-related disease, and cancer as an auxiliary treatment. Nevertheless, the stability of Astaxanthin is relatively bad, so that Astaxanthin could readily degrade or isomerizate without an ideal storage. It’s one of the technical difficulties we need to overcome. Once the stability enhance, the applicability of Astaxanthin will substantially advance.
Nowadays, microencapsulation is well-developed for packaging materials up as cores isolated from the surrounding environment to gain the stability. For example, drugs, cells, and enzymes are common applied materials. Furthermore, it also provides additional effects of masking unpleasant tastes, odors and controlled-release. Several preparation methods were invented, such as spray-drying, fluidized bed coating, extrusion, emulsion phase separation, coacervation, layer-by-layer self-assembly, and microfluidic system.
In this study, Astaxanthin is quantified and qualified by high-performance liquid chromatography. The stability of Astaxanthin would be optimized by controlling the conditions of steps of the microencapsulation preparation process. The formulation is prepared by calcium chloride and sodium alginate which is a member of nature polymers and possesses high biocompatibility. After comparing the size, weight, and morphology of the different formulation particles, we discover the lower the concentration of calcium ion and sodium alginate are, the smaller the particles size is. However, at the concentration of sodium alginate lower than 2%, the microcapsules begin to lose their smooth in appearance and uniformity in morphology. To the consideration above, some formulations are selected and examined the improvement in stability of Astaxanthin by conducting accelerated stability testing. After 3 weeks storage at 25oC and 40oC, the remaining contents of Astaxanthin of four sets at 40oC have reached 85%, other sets have exceeded 90%. On the other hand, at 25oC, all the formulations have exceeded 90% of content. These results inferred the Astaxanthin formulated by microencapsulation have better stability than the original.
| Identifer | oai:union.ndltd.org:TW/098TMC05551009 |
| Date | January 2010 |
| Creators | Yu-Han Tsung, 叢雨涵 |
| Contributors | 許明照 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 97 |
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