碩士 / 中臺科技大學 / 醫學工程暨材料研究所 / 99 / Polysaccharides like chitosan and sodium alginate which are biocompatible, biodegradable and avirulent have been widely applied to bio-medical materials and bio-technology. In addition, Chitosan is anti-bacterial and capable of accelerating healing while alginate possesses more hydrophile groups and thus owns a good swelling rate, qualifying these two materials for wound dressings.
This research prepared a degradable wound dressing by combining chitosan, alginate and PLA/Tencel/absorbent cotton composite nonwoven fabric. The experiment was composed of manufacturing and evaluation of the nonwoven
fabric, the porous film moisture layer, and the resulted composite dressing, respectively. To a wound dressing, its adsorption of tissue fluid and blood as well as its waste disposal were subject to influences of the physical properties of materials selected for making its nonwoven fabric. Comparing to the previous study PLA/absorbent cotton nonwoven fabric, PLA/Tencel/absorbent cotton nonwoven fabric in this study was superior in air permeability, flexibility, tensile strength, tear strength, moisture absorption and vapor permeability, determining the later the base fabric of the wound dressing.Chitosan was made into micro-particle and then blended with alginate/calcium chloride solution for
forming composite solution. The composite solution was made into the swelling layer of porous membrane by freezing drying. The swelling layer was then tested or observed with swelling rate, weight loss rate, water contact angle, anti-bacterial qualitative measurement, Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) as well as in vitro (cell culture and cytotoxic test), determining the optimum parameter of chitosan microsphere was 1 mg/ml; the optimum cross-linking concentration of calcium chloride in 1 wt%
of alginate solution was 0.07 wt%. Finally, nonwoven base fabric and swelling layer of porous membrane were combined by means of halftone coating,forming the alginate/chitosan micro-particle composite dressing. Animal test was conducted and proved the alginate/chitosan micro-particle composite dressing was capable of accelerating wounds’ healing. Furthermore, its porous
structure neither adsorbs tissue fluid nor incurs a second injury while the dressing was removed
| Identifer | oai:union.ndltd.org:TW/099CTC05530002 |
| Date | January 2011 |
| Creators | Shih-Yu Huang, 黃詩育 |
| Contributors | Chao-Chiung Huang, Ching-Wen Lou, 黃昭瓊, 樓靜文 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 128 |
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