碩士 / 義守大學 / 生物醫學工程學系碩士班 / 99 / A controlled pulsatile drug release platform combined with focused ultrasound and alginate microcapsules was established, and enhancement of anti-inflammation efficiency was achieved. An electrospray device (ESD) was employed to fabricate alginate microcapsules with good sphericity and uniform size. These microcapsules were used as carriers for diclofenac (75 % of encapsulation ratio), which was employed as a model drug to evaluate the efficiency of anti-inflammatory.
For in vitro release study, results show that about 30 % higher of drug release rate was obtained by using continuous ultrasound irradiation (with power of 9 W/cm2) than that without ultrasound irradiation. For in vivo study, the anti-inflammatory test with carrageenan-induced rats’ paw oedema shows that, with diclofenac loaded microcapsules followed by ultrasound irradiation, a 81 % of inhibition rate was obtained, which was significantly higher than that of diclofenac with ultrasound irradiation (about 74 %). Ultrasound with appropriate power and pattern can not only bring about predictable release profiles of diclofenac-loaded alginate microcapsules, but also significantly increase the anti-inflammation effects of diclofenac in rats’ paw oedema. In addition, due to the excellent heat conducting properties, encapsulating gold nanoparticles in the diclofenac-loaded microcapsules resulted in better drug release efficiency, but controversially depressed the anti-inflammation effect.
| Identifer | oai:union.ndltd.org:TW/099ISU05114003 |
| Date | January 2011 |
| Creators | Chih-Hsin Chen, 陳智信 |
| Contributors | Chih-Hui Yang, Keng-Shiang Huang, 楊智惠, 黃耿祥 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 56 |
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