碩士 / 國立臺灣海洋大學 / 食品科學系 / 99 / Fucoidan is a complex sulfated polysaccharide with a wide variety of biological activities including anti-oxidant, anti-tumor, immunomodulatory, anti-complement, blood lipids reducing and anti-virus. The six hallmarks of cancer is grown signal autonomy, evasion of grown inhibitory signals, evasion of apoptosis, unlimited replicative potential, angiogenesis and metastasis. Malignant tumor is the leading cause of high death in the world. In fact, metastasis is the major cause of death. However, the effects of fucoidan in anti-migration of tumor cells have not been studied. We find that fucoidan significant impairs migration in vitro through suppression of MMPs activity in Lewis Lung carcinoma cells. We further demonstrated that fucoidan significantly induced the expression of white blood cells and anti-tumor immunity and could act as a strong immunomodulator. On the part of metastasis, increase expression of MMPs and VEGF were observed in a mouse lung carcinoma model, and these were blocked by fucoidan. These results reveal that fucoidan is a novel, effective, anti-migration agent for the treatment of migratory lung cancer risk.
| Identifer | oai:union.ndltd.org:TW/099NTOU5253007 |
| Date | January 2011 |
| Creators | Chin-Nien Chuang, 莊謹年 |
| Contributors | Chang-Jer Wu, 吳彰哲 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 78 |
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