碩士 / 國立臺灣海洋大學 / 食品科學系 / 99 / Glioblastoma multiforme （GBM） is the most aggressive and common kind of brain tumors, few patients suffered from this can survive over 15 months even treated with surgery, chemotherapy or radiotherapy. Since chronic inflammations are associated with malignancies, it is important to prevent inflammation-mediated neoplastic formation, promotion and/or progression. Curcumin and fish oil were both excellent functional foods that can acts as potent anti-inflammatory and anti-oxidative stress agent in our body. However, fish oil is easily oxidized, and the application of curcumin has also been limited by its low bioavailability. In this work, curcumin and fish oil were encapsulated into silica and chitosan, creating curcumin-fish oil-loaded chitosan-silica nanoparticles. The number mean particle size and volume mean particle size of this nanoparticle were 141.36 ± 61.22 nm and 582.37 ± 18.91 nm, respectively. The curcumin encapsulation efficiency of it is 99.94 ± 0.08%. In this research, we found CFCSNP has better anti-tumor activity than fish oil and curcumin alone or even their mixture. It also can decrease inflammation reaction by reducing the production of nitric oxide. We also found that the low dose fish oil might raise the survival rate of tumor cell.
| Identifer | oai:union.ndltd.org:TW/099NTOU5253036 |
| Date | January 2011 |
| Creators | Chi-Chon Kong, 龔吉宗 |
| Contributors | Chang, Ke-Liang, Chen, Jenn-han, 張克亮, 陳振漢 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 102 |
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