碩士 / 靜宜大學 / 食品營養學系 / 99 / Hyperglycemia-induced oxidative damage plays an important role in thrombogenic complications in diabetic patients. Research showed that astaxanthin is a natural food additive with superior anti-inflammatory and antioxidative capacity, however, its effects on diabetic macroangiopathy is unknown. Therefore, the purpose of this study was to investigate the effect of astaxanthin on thrombogenic risk in STZ-induced diabetic rats. Sixty Sprague-Dawley rats were randomly assigned into four experimental groups, including healthy control, diabetic control, diabetic rats with low dose (5 mg/kg BW) of astaxanthin, diabetic rats with high dose (15 mg/kg BW) of astaxanthin. After 8 weeks of feeding period, concentration of fasting glucose, insulin, lipid profile (TG、TC), antioxidative markers (MDA、ROS、GSH), inflammatory markers (CRP、IL-6、TNF-α、MCP-1), coagulation factor VII (FVII), anticoagulation factor (AT-III、PC), plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF) were measured. The results of this study showed that plasma concentration of MDA、ROS and CRP, renal IL-6、TNF-α and MCP-1, concentration of vWF and PAI-1 was significantly decreased in diabetic rats fed with astaxanthin. In addition, renal GSH was significantly increased, and the activity of FVII was significantly decreased in high-dosage astaxanthin fed diabetic rats, when compared to diabetic control rats. In conclusion, feeding high-dosage astaxanthin to diabetic rats may inhibit hyperglycemia-induced oxidative stress. Astaxanthin feeding, by inhibiting pro-inflammatory cytokines secretions, also ameliorates chronic inflammation, hypercoagulability, endothelial damage, and hence decrease the risk of developing thrombogenic complications.
| Identifer | oai:union.ndltd.org:TW/099PU000255023 |
| Date | January 2011 |
| Creators | Pen, Pei-Jain, 潘姵錚 |
| Contributors | Chan, Kung-Chi, 詹恭巨 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 105 |
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