碩士 / 東海大學 / 工業工程與經營資訊學系 / 99 / Purpose：The prevalence of CKD(chronic kidney disease) has become higher and higher in the past few years. CKD patients utilized a lot of resource of health insurance which is limited. Thus, preventing the development of CKD is an important task in the field of prevention medicine. If we can discover the risk factors of CKD more earlier and more accurate, and take adequate action to correct or treat these factors, the prevalence and incidence of CKD may be reduced a lot. As we know, the risk factors of CKD include：old age、family history of CKD、specific race、female gender、DM、metabolic syndrome、high glomerular filtration state、high urine albumin excretion state、dyslipidemia、nephrotoxic agents、primary kidney disease、urinary system disease、cardiovascular disease etc. As many studies revealed, most of CKD have developed before the diagnosis of type 2 DM. Thus, whether impaired fasting glucose, which is also called pre-diabetes, a risk factor of CKD or not, is an important issue that we concerned about.
Method：This is a cross-sectional study. We collected 14175 patients all over 40 years old from adult health checkup from a teaching hospital at west coast area in middle Taiwan. The study period is from January 2006 to June 2010. We collected data of gender、age、past history of hypertension、DM or dyslipidemia、behavior of cigarette smoking、alcohol drinking or betel nut chewing、body height、body weight、blood pressure、fasting blood sugar、total cholesterol、triglyceride、SGOT、SGPT、uric acid、serum creatinine、serum urea nitrogen、serum albumin etc. Exclusion criteria as below：past history of hypertension、DM or dyslipidemia、BMI≧27、systolic blood pressure≧140mmHg、diastolic blood pressure≧90mmHg、fasting blood sugar ≧126 or＜100 mg/dl、total cholesterol≧240 mg/dl、triglyceride≧200 mg/dl、serum uric acid≧9 mg/dl. eGFR(estimated glomerular filtration rate)＜90 ml/min/1.73m2 as an diagnostic criteria of CKD could be obtained via the prediction equation of MDRD(Modification of Diet in Renal Disease) study. Finally we used SPSS statistic software to regression analyze of fasting blood sugar with eGFR.
Results：There are 788 males and 987 females included in this study. The mean eGFR in male group is 90.3 ml/min/1.73m2 (95% confidence interval 88.8~91.7), and is 100.4 ml/min/1.73m2 (95% confidence interval 98.9~101.8) in female group. The difference of mean eGFR in both groups reaches statistical significance, but neither reaches the diagnostic criteria of CKD. In simple regression model of fasting blood sugar with eGFR, both male and female groups reach statistical significance(0.006 in male and 0.000 in female). It means that fasting blood sugar and eGFR do have an inverse relationship, both in male and female groups. In multiple regression model of fasting blood sugar and other biochemistry profiles with eGFR, only uric acid、triglyceride、blood sugar in male group, uric acid、blood sugar、total cholesterol in female group enrolled in the stepwise regression analysis. Though coefficient of determination is low, these factors’ F test in ANOVA reaches statistical significance.
| Identifer | oai:union.ndltd.org:TW/099THU00030017 |
| Date | January 2011 |
| Creators | Hung-Sheng Chen, 陳弘聖 |
| Contributors | Tam Chan, 陳潭 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 38 |
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