碩士 / 中國醫藥大學 / 生物科技學系碩士班 / 100 / Alzheimer''s disease, which is called dementia in general is one kind of brain degenerative nerve disease, mainly characterized by significant and progressive deterioration of memory loss, abnormal language skills, personality changes and deterioration of cognitive function cannot take care their own. As previous study reveals that the brain of patients with memory loss and their secretion of acetylcholine are related to the decrease of nerve cells, making levels of the brain acetylcholine in patients compared with 90% normal difference.
In this study, the ingredients of Chinese herbs Shu di Huang for the efficacy of Alzheimer''s disease, and compared with the chemical acetylcholine synthesis inhibitor. Therefore, we want to study medicine Shu di Huang as the main drug, the drug Shu di Huang structure and Alzheimer''s disease in the enzyme structure of acetylcholine on the experiment of Shu di Huang inhibitory effect of acetylcholine, Discovery Studio® experimental program will mainly use acetylcholine Shu di Huang molecular structure of the enzyme and the binding between the simulation and analysis using Docking program to evaluate its drug activity. The experimental results obtained show that component of the preliminary test results Shu di Huang catalpol the assessment of drug activity to obtain a good docking score, future experiments will further explore whether the structure of other components of Shu di Huang is also able to acetylcholine enzyme inhibition, to be confirmed as soon as these components can be studied in the near future.
| Identifer | oai:union.ndltd.org:TW/100CMCH5111001 |
| Date | January 2012 |
| Creators | I-Chen Chiang, 江浥塵 |
| Contributors | 林如華 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 55 |
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