碩士 / 中國醫藥大學 / 營養學系碩士班 / 100 / Alzheimer''s disease (AD) is a progressive and irreversible neurodegenerative disease. The study showed that 80% of Alzheimer''s disease patients have type 2 diabetes or abnormal blood glucose levels. Many research used an Alzheimer''s disease animal model for intracerebral injection of streptozotocin. However, the pathological characteristics did not completely reflect in animals with type 2 diabetes. The purpose of the study was to investigate the effects of related risk factors on Alzheimer’s disease biomarkers by using animal model of type 2 diabetes. The animals in this study were divided into five groups: Normal group(WKY rats); Control group(SHR); SS group(SHR rats, 40mg/kg STZ for short); HF group(high fat diet); DM group (high-fat diet and injection of 40mg/kg STZ). During the study period, blood glucose, blood pressure, triglycerides, insulin, insulin receptor, oxidative stress, inflammatory markers, choline acetyltransferase, amyloid precursor protein(APP) and β amyloid-42(Aβ42) were detected. After STZ injection, the largest changes of insulin and plasma APP were shown in DM group. Furthermore, a significant high correlation was also shown in hepatic triglyceride and serum Aβ42 protein level(R2 =0.4174，p<0.05)；The brain insulin receptor activity was significantly decreased and the accumulation of brain Aβ42 was significant increased in DM group. The results show that blood pressure, oxidative stress and inflammatory biomarkers were not influential factors to APP and Aβ42 during the experiment. In conclusion, diabetes progression could affect the related biochemical markers of Alzheimer''s disease. Thus, insulin resistence may be highly related to Alzheimer’s disease progression.
| Identifer | oai:union.ndltd.org:TW/100CMCH5513001 |
| Date | January 2012 |
| Creators | Ya-Chun Hu, 胡雅淳 |
| Contributors | 楊惠婷 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 104 |
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