碩士 / 逢甲大學 / 纖維與複合材料學系 / 100 / Dressings were used our daily life when the body is injured. Nowadays, there are many different kinds of dressings occur in the market. Multi-functional dressings have emerged for satisfying the requirements for human. However, dressings still have a part of functionality that remains to improve, such as adherence with wounds, bad air permeability, poor absorbability to tissue fluid. Hence, excellent dressings should have properties of good air permeability, hygroscopicity, easy removal and accelerating wound healing for effect of wound healing.
This study divides into three parts. The first is preparation of functional dressing fabric that is composed of PLA and Tencel® fibers. In this part, the optimal processing parameters of fabric are found by adjusting to the blending ratios of fibers and evaluating the strength, air permeability, softness, and water vapor permeation. The second is (a) the preparation of Sodium Alginate dressing as wound contact layer, (b) the extraction of Lithospermum erythrorhizon and (c) the preparation of Sodium Alginate/ Pectin microcapsules. The contact layer is evaluated by swelling ratio, moisture retention and vitro degradation. The shikonin extraction is characterized by extraction rate, antimicrobial activity and cell biocompatibility, and microcapsules are assessed in terms of hydrophilia, drug release, and MTT assay. The third is the preparation of composite dressings that are made by PLA/Tencel® nonwoven fabric, shikonin microcapsule and Sodium Alginate based on 3D lattice-point coating. Afterwards, the composite dressings are evaluated by mechanical performance and animal experiment.
The experimental results show that, the optimum blending ratio of PLA and Tencel® fibers is 50 wt%: 50 wt%. The optimum wound contact layer contains 1wt% sodium alginate, and 0.066 wt% Calcium chloride cross-linking agent. The cell survival rate rises up to 99 % when microcapsules comprise 1mg/ml of shikonin solution, and 1:1 sodium Alginate and Pectin. Animal experiment results reveals that, PLA/Tencel® composite dressings after being coated with sodium alginate and then shikonin microcapsules, the wound almost cures completely by 11 days after operation; comparatively, the wound only heals 91.5 % after 15 days postoperation when using market dressings. This indicates that, shikonin microcapsules/sodium alginate coated PLA/Tencel® composite dressings accelerate the effect of wound healing.
| Identifer | oai:union.ndltd.org:TW/100FCU05292026 |
| Date | January 2012 |
| Creators | Zong-Han Wu, 吳宗翰 |
| Contributors | Jia-Horng Lin, 林佳弘 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 200 |
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