碩士 / 高雄醫學大學 / 醫學影像暨放射科學研究所 / 100 / Alzheimer’s disease (AD) is the most common cause of dementia of elderly life. In order to understanding the relationship between AD and ACE inhibitors, the SH-SY5Y was treated with ACE inhibitors and the protein were analyzed by Reverse-phase-nano-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (RP-nano-HPLC-ESI-MS/MS) followed by peptide fragmentation patterning. In this study, three proteins, Low-density lipoprotein receptor-related protein 1B, Calreticulin and 14-3-3 protein zeta/delta, were identified and their expression were up-regulated. These proteins may contribute to the increase concentrations of beta-amyloid and phosphorylated Tau. Our results suggest that ACE inhibitors may play an important role in acceleration of the progression of clinical symptoms of AD.
| Identifer | oai:union.ndltd.org:TW/100KMC05605003 |
| Date | January 2012 |
| Creators | Yuh-Shan Su, 蘇育賢 |
| Contributors | Yu-Chang Tyan, 田育彰 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 83 |
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