碩士 / 國立屏東科技大學 / 動物科學與畜產系所 / 100 / Spirulina (Arthrospira spp., commonly known as cyanobacteria) is an edible alga, which is rich in proteins, essential amino acids, essential fatty acids, vitamins and minerals, and other nutrients. The Spirulina contains a special pigment carrying protein (C-phycocyanin, CPC). The CPC has effects on antioxidation, reduces liver lipid peroxidation, antibacteria, antitumor and immunoregulation, which could be ideal materials for health food. In this current paper, the effect of Spirulina on protection of liver and the mechanisms were studied to develop a health food for liver protection, since the liver disease is one of the main diseases in Chinese. The chronic chemical liver injury rat model was induced with carbon tetrachloride (CCl4). The effect of different doses of CPC protection effect and mechanism on liver cells were detected. The liver function analysis indicated that the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in sera of the model rats induced by CCl4 was significantly decreased (P<0.05) by the treatment of CPC comparing with that of the negative control rats. In liver tissues from the rats treated with high dose of CPC, the antioxidant enzymes, including SOD, Catalase, GSH and GSH-PX, were also increased significantly compared with that of the negative control group (P<0.05). The pathological observation showed that the pathological phenotype of cavitation of degeneration, liver cell swelling, necrosis, fibrosis were obviously improved by the treatment of CPC. In summary, the results indicated that the CPC treatment increased the levels of the antioxidant enzymes in liver and improved the liver function in the rat model of CCl4 induced chronic liver injury, and suggesting that antioxidant enzymes inducible activity of CPC could be one of mechanisms of liver protection. Our founding was also suggested that CPC could be a potential health food for liver protection.
| Identifer | oai:union.ndltd.org:TW/100NPUS5289014 |
| Date | January 2012 |
| Creators | 萬英群 |
| Contributors | 劉炳燦 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 100 |
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