碩士 / 東海大學 / 生命科學系 / 100 / Early morphogenetic movements of interrenal tissue, the equivalent of the adrenal cortex, are promoted by peri-interrenal angioblasts and the axial vasculature. In this study, we identified the interrenal vessel (IRV) which develops from dorsal aorta (DA) as early as 2 days post fertilization (dpf). The angiogenic invasion and formation of IRV were temporally correlated with central migration of steroidogentic interrenal cells, as well as the integration between the interrenal and chromaffin cells. During this process of dynamic tissue-tissue interactions, the extracellular protein Fibronectin (Fn) was distributed at the junction between interrenal tissue and the axial vasculature. Also, it was expressed along the direction of intra-interrenal angiogenesis as well as that of interrenal relocalization. Fn is an extracellular matrix glycoprotein which is important for cell adhesion, growth, migration and differentiation. Genetic mutant and morphant analyses revealed that the loss of Fn protein at the peri-interrenal area did not affect specification and differentiation of the steroidogenic interrenal tissue. However, central migration and angiogenic invasion of steroidogenic cells were both inhibited upon the knockdown of Fn. Our results thus suggested a role of Fn for mediating intra-interrenal angiogenesis.
| Identifer | oai:union.ndltd.org:TW/100THU00112006 |
| Date | January 2012 |
| Creators | Chiu, Chihhao, 邱志豪 |
| Contributors | Liu, Yiwen, 劉薏雯 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 66 |
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