碩士 / 中國醫藥大學 / 醫務管理學系碩士班 / 101 / Objective: Currently Statins are the strongest effect and were used the most widely for lowing cholesterol, and cholesterol is a risk factor of Alzheimer''s disease. In this study, we decided to investigate the correlation analysis of Statins, cognitive impairment, dementia and Alzheimer’s disease.
Method: Based on Longitudinal Health Insurance Database (LHID2005) in National Health Research Institutes within 2001-2010, the patients who were diagnosed cognitive Impairment (ICD-9 code: 438.0, 438.1, 310.1), dementia (ICD-9 code: 290, 294.1), Alzheimer’s disease (ICD-9 code: 331.0) within 2001-2010 were selected as the research subjects. Cox Proportional Hazard Model was applied to analyze the Statins and cognitive-related disease risks.
Result: The research subjects are 824,997 people within 2001-2010. The number of Statins user is 14,491 (1.76%). Overall, the Statins users'' risks of occurrimg cognitive-related diseases were 1.37 times of nonusers'' (95% CI : 1.27-1.47); age and cognitive-related diseases had significant differences (p<0.001), Thou who were older had higher risks; Male’s risks of occurreding cognitive-related diseases were 0.94 times of female’s(95% CI : 0.91-0.96); Cerebrovascular disease, history of Traumatic Brain Injury, Central Nervous System Infections and Neoplasm of brain were higher than those who didn’t have.
Conclusion: The result indicated that those who used Statins can increase the risk of occurring dementia. This result can provide a information for the medical treatment units.
| Identifer | oai:union.ndltd.org:TW/101CMCH5528020 |
| Date | January 2013 |
| Creators | Yi-Jing Huang, 黃奕菁 |
| Contributors | 黃光華 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 65 |
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