碩士 / 嘉南藥理科技大學 / 化粧品應用與管理系暨化粧品科技研究所 / 101 / In this study, Astaxanthin and β-Arbutin were co-encapsulated in liposome to avoid oxidation and degradation of those compounds. The physical properties such as differential thermal analysis, particle size, zeta potential, encapsulation efficiency, stability study, and vesicle-skin interaction study by STEM and in vitro skin penetration were evaluated in this study. Two phospholipids including unsaturated phospholipids(Epikuron200) and saturated phospholipids (LS-60HR) were employed for the preparation of liposome in this study. The phospholipids and Astaxanthin were first dissolved in propylene glycol.Then injected in water containing β-Arbutin with stirring at 700 rpm. The PG-liposome solution was homogeneous by high pressure homogenizers at 500bar 10cycles.
The experimental results showed that Showed that if the content propylene glycol is higher, the particle size is smaller, even to approximate 40nm and the encapsulation efficiency is higher, but between particles electrostatic force is lower. The PG-liposome prepared by LS-60HR and 15% propylene glycol can be Stabe for 3 months. The above formulations also showed higher transdermal flux across the skin as compared with that of conventional Essence. Fluorescence microscope images studies revealed that liposomes influenced the ultrastructure of epidermis. The results of the characterization studies indicate that PG-liposomes vesicles for improving skin permeation.
| Identifer | oai:union.ndltd.org:TW/101CNUP0115001 |
| Date | January 2013 |
| Creators | Chen,Hongjie, 陳虹潔 |
| Contributors | Lin,Weichao, 林維炤 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 124 |
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