碩士 / 輔仁大學 / 營養科學系碩士班 / 101 / Cell line and animal model had indicated that folate supplementation could help lower homocysteine levels and decrease oxidative stress. We have previously reported that folic acid potentiated effects of Alzheimer’s disease (AD) drug on neuronal protection in early-stage AD development. Folic acid is a kind of nutrient supplement, and folinic acid is a clinical cancer drug. However, in this study, the treatment of late-stage AD with folate derivatives in 3xTg-AD transgenic mice was investigated. Forty 3xTg-AD mice at 16 month-old were divided into three groups fed with the diet in the absence (Control) or presence of folic acid (FA) and folinic acid (FN) supplements (12 mg/kg/day by force feeding). Spatial memory function was assayed by water-maze test before mice were sacrificed at 19 month-old. The data revealed that FA and FN groups had significantly higher levels of serum folate than the controls group after 3 month supplementation (p<0.05). The AD neuropathological markers of Aβ40, Aβ42 or phosphotau levels were significantly lower in the brains of FA and FN groups as compared with the controls (p<0.05). Although these reduced brain pathological severity by FA or FN supplement were not associated with cognition improvement, survival rates of FA (69%) and FN groups (86%) was 1.6 fold-increased in relative to the controls (54%) at 19 month-old. Taken together, the data demonstrated that FA and FN treatments may alleviate pathological severity of late-stage Alzheimer’s disease associated with increased survival rate of 3xTg-AD mice.
| Identifer | oai:union.ndltd.org:TW/101FJU00513011 |
| Date | January 2013 |
| Creators | Hung-Cheng Hsu, 許弘政 |
| Contributors | Rwei-Fen S.Huang, Ta-Fu Chen, 許瑞芬, 陳達夫 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 62 |
Page generated in 0.0122 seconds