碩士 / 弘光科技大學 / 營養醫學研究所 / 101 / Abstract
Chronic wound is defined as any wound not in accordance with the expected time to heal or stay in a healing process more than more than four to six weeks. That cause cell damage and a series of oxidation reaction when the body's antioxidant capacity can not be excessive reactive oxygen radicals catabolism continuity of the vicious cycle will make the wound a long period of chronic inflammatory conditions, is also a major factor in wound healing adverse. This study as the research object to the most common chronic wounds, pressure sores, analysis of the pathophysiology of pressure sores, and involved in the analysis of oxidative stress through antioxidant nutritional supplements, the correlation between the degree of wound infection and healing speed, hoping to intervention by antioxidant nutritional supplements, inflammatory condition of patients improve, accelerate wound healing, and then evaluate the feasibility antioxidant nutritional supplements adjuvant treatment of pressure ulcers wounds. Respiratory care ward, rehabilitative medicine and other chronic hospitalization and problem wounds outpatient chronic wounds of patients for the study sample of 23 people, 10 males and 13 females. Experimental design of the control group (without any nutritional supplements), experimental group A (unilateral fish oil nutritional supplements), experimental group B (vitamin C, protein powder and fish oil nutritional supplements), three sets of clinical trials of subjects and taking supplement twice a day for four weeks. During experiment period, on a regular basis to detect body nutrition, inflammation, oxidative stress indicators.
Result: the group B and control group compared to CRP and ESR was no significant difference before the experiment, but showed significant differences after the experiment.Group B got away from acute inflammatory stateand reduce acute and chronic inflammation
IV
markerssuccessfully within one month. Group Aalso decreased the inflammatory immune response (IL-1β, IL-6 and TNF-A). Compound fish oil nutritional supplements had no significant associationwith oxidative stress (catalase, GPX, MDA) in this present study.The group B, with statistically significant differences in the progress of the wound scores compared with the control group.
Conclusion: ω-3 polyunsaturated fatty acids in patients with chronic wounds, not suppress immunity (T-lymphcyte), but to reduce the inflammation of the immune response (IL-1β, IL-6 and TNF-A), accelerated chronic wound healing (NPUAP classification), and the effects of compound fish oil nutritional supplements is better than unilateral fish oil nutritional supplements.
| Identifer | oai:union.ndltd.org:TW/101HKU05513002 |
| Creators | Chen, Te-Chung, 陳德忠 |
| Contributors | 王瑞蓮 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 88 |
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