碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 101 / To date, some mammalian animal models were established for screening new drugs and investigating the mechanisms of epilepsy. However, there were several limits in mammalian model, such as higher costs in breeding, nursing, bigger size and higher dosage. Recently, zebrafish (Danio rerio) had become a potential model animal, which has some advatnges, such as lower dosage to mammalian, a short reproductive cycle with massive amount of offspring, and its gene homologous to human for 70-80%. Moreover, zebrafish, with a fully developed nervous system, would be a suitable model animal for exploring and analyzing of human CNS disease. Our results revealed that the epilepsy-like zebrafish model could be attenuated by clinical drugs. Therefore, we intended to use this model for a rapid in vivo screening of threaprutic compounds in the future.
| Identifer | oai:union.ndltd.org:TW/101NSYS5277005 |
| Date | January 2013 |
| Creators | Yi-Shin Lin, 林怡馨 |
| Contributors | Zhi-Hong Wen, 溫志宏 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 88 |
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