碩士 / 中國醫藥大學 / 營養學系碩士班 / 102 / Type 1 diabetes mellitus (T1DM) is an autoimmune disease caused by T-cell mediated destruction of pancreatic β-cells, which leads to insulin deficiency. Our previous studies found that intake of Houttuynia cordata Thunb aqueous extract (HCE) improved the high-fat-diet induced lipid disorders in mice; and provided hepatoprotective effects against APAP-induced injury in mice via its antioxidant and anti-inflammatory capacity. Therefore, the aim of this present study was to determine whether HCE could attenuate oxidative and inflammatory stress in STZ-induced diabetic mice. Male C57BL/6JNarL mice were i.p. 45 mg/kg/day STZ for consecutive 5 days to induced diabetes. Experimental design was divided into normal group (n = 10), DM group (n = 15), DM + 4% HCE group (n = 15), DM + 8% HCE group (n = 15). After 11 weeks supplementation, mice were sacrificed; blood and organs were collected for analyses. Results showed that the intake of HCE significantly improved hyperglycemia, hypoinsulinemia; increased the GSH level and GPx, SOD, CAT activities of heart; decreased renal IL-6, TNF-α and MCP-1 level. Furthermore, HCE intake attenuated renal AGEs level. These findings indicated that Houttuynia cordata Thunb could delay diabetic progression.
| Identifer | oai:union.ndltd.org:TW/102CMCH5513018 |
| Date | January 2014 |
| Creators | Jing-Jing Ho, 何菁菁 |
| Contributors | Mei-Chin Yin, 殷梅津 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 82 |
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