碩士 / 嘉南藥理科技大學 / 化粧品應用與管理系 / 102 / In this study, the thermo-sensitive Poly(N-isopropylacrylamide-co-N-methylol acrylamide (poly(NIPAAm-NMA)) and fish peptide were used as materials to manufacture the electrospun fibers by the method of electrospinning. The effects of various variables on the morphology of electrospun fibers were investigated. In order to stabilize the morphology of the electrospun fibers, the poly(NIPAAm) segments were crosslinked by heating process, and the glutaraldehyde and1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) were used to crosslinked the peptide segments respectively. Moreover, the electrospun fibers were used as drug carriers to load with the model drug, caffeine. The caffeine was loaded into the electrospun fibers by the method of swelling process and electrospinning process respectively. The effect of loading methods on the caffeine release rate was investigated.
| Identifer | oai:union.ndltd.org:TW/102CNUP0115001 |
| Date | January 2013 |
| Creators | Tsung-Yuan Wu, 吳宗遠 |
| Contributors | Chia-Fen Lee, 李佳芬 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 95 |
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