碩士 / 中山醫學大學 / 生化暨生物科技研究所 / 102 / Small GTPase are a family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). The most well-known members are the Ras GTPases and which sometimes called Ras superfamily GTPases. Over the past years, researchers have identified many components of the pathway that mediate Ras activation and effector function. The Ras proteins function as regulated GDP/GTP switches that cycle between active GTP-complex and inactive GDP-complex states. Additionally, Ras regulator the actin filament system, and regulate actin dynamics.Rho proteins have also important roles in regulating the organization of actin dynamics. Recent studies have shown the association between GTPase and neurodegenerative diseases (e.g. Alzheimer, Parkinson’s). Here, we identify a new ras member diras2 which belongs to a distinct branch of the GTPase family, but has a distinct mechanism of hydrolysis. DiRas2 predominantly expressed in brain. Our data show that Diras may be involved in novel cellular functions distinct from other Ras-related GTPases.
| Identifer | oai:union.ndltd.org:TW/102CSMU5107035 |
| Date | January 2014 |
| Creators | Shih-Wei Huang, 黃世維 |
| Contributors | 許立松 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 44 |
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