碩士 / 輔仁大學 / 生命科學系碩士班 / 103 / Alzheimer disease (AD) is the most common form of dementia and a complex disorder of the central nervous system that affects numerous people worldwide due to the overall aging of human. There is no cure for the disease, which worsens as it progresses, and eventually leads to death. Different clinical outcomes of AD patients were obtained across races. For example, Caucasians with AD may have worse survival compared with African Americans and Latinos. There is no reasonable explanation for the ethnic survival differences and underlying genetic effects may be responsible. Here we identify potential AD associated single-nucleotide polymorphisms (SNPs) and compare their carrier frequencies (CFs) between different populations. A total of 103 SNPs associated with AD based on genome-wide association studies (GWAS) were found through literature review. Some mutations were significantly different between different races and have the highest or lowest CFs among Caucasians. Results also showed that mutations could be potentially responsible for the ethnic survival differences. Determining the underlying genetic factors behind survival differences may also contribute to further researches related with AD survival and lead to improve survival for AD patients of all ethnics.
| Identifer | oai:union.ndltd.org:TW/102FJU00105017 |
| Date | January 2014 |
| Creators | Hsiao Ming Yi, 蕭明怡 |
| Contributors | Hour Ai Ling, 侯藹玲 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 61 |
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