碩士 / 高雄醫學大學 / 天然藥物研究所 / 102 / The research topic of this thesis focuses on new natural product investigation from Taiwanese indigenous sea anemone. A zoanthid identified as Zoanthus kuroshio was extracted and subjected to a series of column chromatograph. As a result, nine new alkaloids named kuroshines A-I (1-9) and one know compound (10) were purified and identified. The isolates possess a densely functionalized ring system on the basis of the zoanthamine frames. It is noted that kuroshine A (1) is the first zoanthamine-type alkaloid with an ether bridge between C-10 and C-28 and kuroshine B (2) is the first zoanthamine-type alkaloid with an ester bridge between C-24 and C-26. They demonstrate a great structural diversity of Taiwanese zoanthid and new compounds (3-7) are recognized as a series of oxidation products of 1. The structures of all compounds were elucidated through interpretation of spectroscopic methods, especially 2D NMR techniques (COSY, HMQC, HMBC, and ROESY). The absolute stereochemistry of 1 was further confirmed by an X-ray single crystallographic analysis using a mirror Cu-Kα radiation. By the way , the species of research materials was identified by the mt16s rDNA sequencing method and morphology. This is the first studying combined natural product investigation and species identification for Taiwanese indigenous zoanthids.
| Identifer | oai:union.ndltd.org:TW/102KMC05068016 |
| Date | January 2014 |
| Creators | Chih-Chin Lan, 藍智勤 |
| Contributors | Yuan-Bin Cheng, 鄭源斌 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 96 |
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