碩士 / 國立成功大學 / 工程科學系 / 102 / SUMMARY
This thesis presents a microfluidic fusion chip for generating ca-alginate microcapsules with different concentrations. Using MEMS technology, we designed and fabricated a PDMS microfluidic chip, which contained a micron rating 3D electrode as a replacement for the planar electrode made of indium tin oxide, a pillar-induced fusion zone, and an s-shaped observation zone. We used this microfluidic chip to generate ca-alginate microcapsules uniformly sized but covered in different bovine serum albumin (BSA) concentrations, and found that the sizes ranged between 181 m and 161 m. After putting the three differently-sized microcapsules and three different BSA concentrations into Phosphate Buffered Saline for drug release, we observed through the UV/Visible Absorption Spectrometer that the Ca-alginate generated by microfluidic chip could release different drug concentrations at the same time. Thus, the proposed microfluidic chip can be applied to producing microcapsules of different sizes and with different drug concentrations.
Keywords: MEMS, microfluidics chip, sheath flow, polarization, calcium alginate microcapsules, BSA
| Identifer | oai:union.ndltd.org:TW/102NCKU5028104 |
| Date | January 2014 |
| Creators | Shen-YangLin, 林紳煬 |
| Contributors | Yu-Cheng Lin, 林裕城 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 98 |
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