碩士 / 國立成功大學 / 化學工程學系 / 102 / Recently, magnetic electrospun mats were established as an innovative biomaterial for hyperthermia treatment of cancer therapy. Unlike those surface-modified magnetic nanoparticles that may not firmly adhere onto the tumor site for long-term duration, the magnetic mats with nanofibrous structure can promote cell adhesion and kill the tumor cells within an alternating magnetic field (AMF). However, most published magnetic electrospun mats were fabricated using non-biodegradable polymers and organic solvents, which has led to the issues related to the removal of electrospun mat after therapy as well as the toxicity issue about the residual solvent. To overcome these problems, alginate, which is biodegradable and water-soluble, was utilized in this study as the main material for electrospinning. The alginate-based electrospun mats were crosslinked by an ionic or a covalent method prior to a chemical precipitation for magnetic nanoparticles. Various analyses for the mats were conducted to understand their molecular composition, morphology, crystallinity, chelation ability and magnetic properties. The final magnetic products, termed as Fe3O4-SA/PEO mat and Fe3O4-SA/PVA mat, both showed non-cytotoxicity as examined by the cell proliferation assay. For the in vitro hyperthermia effect, the magnetic alginate-based mats have reduced tumor cells proliferation in the AMF more than the Fe3O4 nanoparticles did. Such magnetic electrospun mats are of potential for endoscopic/surgical delivery for hyperthermia treatment and debridement after surgical removal.
| Identifer | oai:union.ndltd.org:TW/102NCKU5063087 |
| Date | January 2014 |
| Creators | Yen-HsuanChen, 陳彥勲 |
| Contributors | Jui-Che Lin, 林睿哲 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 92 |
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