碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 102 / In recent years, marine organism-derived peptides have been identified as new and potential sources for drug development. Recently, we found that the marine organism-derived peptide, PCD-1 was biologically active, and previous studies have indicated that it have anti-inflammatory properties. The neuroinflammatory processes are known to play a critical role in the development and maintenance of neuropathic pain, for which no effective drugs are currently available. In the present study, we investigated the anti-analgesic and anti-neuroinflammatory effects of the PCD-1 on chronic constriction injury-induced neuropathy in rats. We found that intrathecal injection of PCD-1 produced a significant and dose-dependent inhibition of thermal hyperalgesia, mechanical allodynia, weight bearing, and cold allodynia in neuropathic rats after CCI surgery. Moreover, it also attenuated CCI-induced spinal neuroinflammation. On the basis of these experimental results, we suggest that PCD-1 could be used as a potential therapeutic agent for neuropathic pain.
| Identifer | oai:union.ndltd.org:TW/102NSYS5277001 |
| Date | January 2013 |
| Creators | Chang-yi Liao, 廖倉億 |
| Contributors | Zhi-Hong Wen, 溫志宏 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 112 |
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