碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 102 / Investigation on the chemical constituents of the ethyl acetate extract of the soft coral Sinularia nanolobata, led to the isolation of seven new compounds, including three new cubitane-type diterpenoids, nanolobones A–C (1–3), three new cembrane-type diterpenoids, nanolobols A–C (4–6) and a new steroid glycoside 24-methylenecholest-5-ene-3β,11α,16β-diol
-3-O-α-L-fucoside (7) along with twelfth know compounds. nanolobones A–C are new examples of diterpenoids of the irregular cubitane ring system, which was first isolated in 1978 from the East African termite. In addition, nanolobols A–C featured unusual 19-oxygenated functionalities, which are rarely found from cembranoid analogues.
The structures of these compounds were elucidated on the basis of spectroscopic methods and by comparison with those of the related known compounds. The cytotoxicity of compounds 2– 5, 7–19 against the growth of three cancer cell lines, including murine leukemia (P-388), human chronic myelogenous leukemia (K-562) and human colon carcinoma (HT-29) cell lines were determined. The results showed that compound 16 exhbited cytotoxic activity toward P-388, K-562, HT-29 cancer cell lines with IC50 values of 15.54 ± 2.26, 15.83 ± 4.51 and 12.62 ± 3.27 μM, respectively. The anti-inflammation activity of compounds 2–19 was also studied. Compound 16 was found to inhibit the production of superoxide anion and elastase with IC50 values of 14.87 ± 1.43 and 6.55 ± 1.01 μM, respectively.
| Identifer | oai:union.ndltd.org:TW/102NSYS5277020 |
| Date | January 2014 |
| Creators | Chia-yun Wu, 吳佳芸 |
| Contributors | Jhy-Horng Sheu, 許志宏 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 219 |
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