碩士 / 國立臺灣海洋大學 / 水產養殖學系 / 102 / The objective of present study was to investigate the tissue distribution and elimination of sulfadimethoxine in hybrid red tilapia (Orechromis sp.). Hybrid red tilapia (Oreochromis sp.) were force fed with SDM at the dose of 100 mg/kg/day for five consecutive days. Plasma and tissues (muscle, skin, liver, bile and head kidney) were sampled at 1, 12, 24, 48, 96, 168, 336, 504, 720 and 1080 hour after treatment.
The results of residue depletion study showed that plasma, muscle and skin samples reach maximum concentrations (Cmax) of SDM at 1 hour post-treatment. The liver and head kidney samples reach maximum concentrations of SDM at 24 hour post-treatment. The bile samples reach maximum concentrations of SDM at 12 hour post-treatment. Comparatively higher SDM levels were found in liver and bile, whereas similar SDM concentrations were found in plasma, muscle, skin and head kidney.The elimination half-lives(t1/2) for plasma, muscle, skin, liver, bile and head kidney were 32.71 hour、29.79 hour、32.71 hour、27.86 hour、39.08 hour and 31.35 hour respectively. Concentration of SDM in muscle was already lower than the LOD of TFDA(0.01 ppm) at 504 hour post-treatment. Concentration of SDM in head kidney was already lower than the LOD at 720 hour post-treatment. Concentration of SDM in plasma and skin was already lower than the LOD at 1080 hour post-treatment. Concentration of SDM in liver and bile was still higher than the LOD at 1080 hour post-treatment.
| Identifer | oai:union.ndltd.org:TW/102NTOU5086094 |
| Date | January 2014 |
| Creators | Shiau, Ming-Lung, 蕭名儂 |
| Contributors | Nan, Fan-Hua, 冉繁華 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 48 |
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