碩士 / 國立臺灣海洋大學 / 食品科學系 / 102 / The cause of diabetes often linked with chronic inflammation. However, most of the ways for improving diabetes through improves the blood glucose, rarely using balanced immune system as a basis treating diabetes, so diabetes induced inflammatory can restored to normal level. There are no research about anti-inflammatory functions with diabetes on Fucoxanthin. In this study was investigated Immunomodulatory Function of Fucoxanthin in STZ-induced Diabetic Mice. Male BALB/c mice were induced into diabetes by nicotinamide (230 mg/kg) and streptozotocin (65 mg/kg). Then, orally gave fucoxanthin at the doses of 4.1, 8.2 and 20.5 mg/kg body weight for 8 weeks. Then assessed the non-specific immune responses including phagocytosis, spleen cells proliferation, cytokines secretions, IgG and IgM productions and Macrophage 1, Macrophage 2 indicator. The results were shown that fucoxanthin could reduce the body weight, inhibited IgM, IL-6 and TNF-α production, increased the activaty of phagocytosis and spleen cell proliferation whereas those effects were not significantly shown on the drug called rosiglitazone. Moreover, the aspects of suppressing the pro-inflammatory cytokines and boosting the immune system in diabetes mice with high dosage of fucoxanthin were able returning to normal level as like as control group. However, in the adipose tissue, the drug and fucoxanthin does not affect the M1 phenotype, but inhibited M2 phenotype.
| Identifer | oai:union.ndltd.org:TW/102NTOU5253044 |
| Date | January 2014 |
| Creators | Lau, Wun-Man, 劉媛文 |
| Contributors | Kong, Zwe-Ling, 龔瑞林 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 44 |
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