碩士 / 靜宜大學 / 食品營養學系 / 102 / Macrovascular complications are the major causes of death among diabetic patients, and hyperglycemia-induced oxidation and subsequent chronic inflammation play an important role in the etiology of diabetic macroangiopathy. Astaxanthin (AX) is one of the carotenoids with excellent anti-inflammatory and antioxidative capacity; therefore, the purpose of this study was to investigate the effect of astaxanthin and astaxanthin formula (AXF) on thrombogenic risk in type 2 diabetic patients. One hundred and three type 2 diabetic patients were recruited from Cheng Ching Hospital in Taichung city. After exclusion of unqualified patients, all subjects were randomly assigned into three treatment groups including placebo group (P), AXF (AX 6 mg + vitamin E 150 mg + Tocotrienol 45 mg/day) group and AX (AX: 14 mg/day) group, respectively. After two month’s supplementation, plasma concentration of AX, fasting blood glucose (FBG), HbA1c, lipid profiles, markers of hepatic and renal function, oxidative and inflammatory markers, coagulation and anti-coagulation factors were measured. The results showed that plasma levels of AX increased by supplementation in a dose-dependent manner. Plasma concentration of HbA1c, CRP and vWF was significantly decreased in AXF group. Plasma concentration of HbA1c, TG and TC, GPT, inflammatory cytokines of TNF-α, CRP and vWF was significantly decreased in AX group. In addition, plasma concentration of coagulation factor VII and PAI-1 was significantly decreased, and AT-III level was significantly increased in AX group. In conclusion, AX supplementation for two months may have beneficial effects on type 2 DM patients in ameliorating hyperglycemia, hyperlipidemia and liver malfunction. AX supplementation also decreases oxidation stress and inhibits chronic inflammation, hence ameliorates endothelial damage and thrombogenic risk in type 2 DM patients.
| Identifer | oai:union.ndltd.org:TW/102PU000255014 |
| Date | January 2014 |
| Creators | CHEN, PEI-CHI, 陳沛綺 |
| Contributors | CHAN, KUNG-CHI, 詹恭巨 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 124 |
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